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产品信息
PA5-21953
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 111 and 175 of RAMP2 (Uniprot ID#O60895)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11154090
产品详细信息
Recommended positive controls: Jurkat, Raji, K562, THP-1, HL-60, NCI-H929.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcitonin receptor-like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2; OTTMUSP00000002615; OTTMUSP00000037624; receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; Receptor activity-modifying protein 2; receptor-activity-modifying protein 2; RP23-281C18.6
基因别名: RAMP2
UniProt ID: (Human) O60895
Entrez Gene ID: (Human) 10266
angiogenesis
vasculogenesis
response to hypoxia
sprouting angiogenesis
cAMP biosynthetic process
calcium ion transport
intracellular protein transport
G-protein coupled receptor signaling pathway
heart development
female pregnancy
regulation of blood pressure
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of gene expression
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
response to estradiol
response to progesterone
cellular response to hormone stimulus
adherens junction assembly
cellular response to vascular endothelial growth factor stimulus
negative regulation of vascular permeability
positive regulation of angiogenesis
bicellular tight junction assembly
basement membrane assembly
protein localization to plasma membrane
vascular smooth muscle cell development
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
