Invitrogen

RAMP2 Polyclonal Antibody

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RAMP2 Antibody (PA5-47846) in WB

Western blot analysis of RAMP2 in D3 mouse embryonic stem cell line. Samples were incubated in RAMP2 polyclonal antibody (Product # PA5-47846) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. A specific band was detected for RAMP2 at approximately 20 kDa (as indicated). This experiment was conducted under reducing conditions.

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产品信息

PA5-47846

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

流式细胞分析 (Flow)

2.5 µg per million cells

产品规格

种属反应

Mouse

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

E. coli-derived recombinant mouse RAMP2 Ser45-Val159

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2576471

产品详细信息

In direct ELISAs, approximately 25% cross-reactivity with recombinant human (rh) RAMP2 is observed, and less than 1% cross-reactivity with rhRAMP1 is observed.

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

靶标信息

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

仅用于科研。不用于诊断过程。未经明确授权不得转售。