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RAMP2 (extracellular) Antibody (ARR-022-200UL) in WB
Western blot analysis of rat lung (lanes 1 and 4, 1:200), mouse heart (lanes 2 and 5, 1:200) and rat aortic endothelial cell (RAEC) (lanes 3 and 6, 1:400) lysates: - 1-3. Anti-RAMP2 (extracellular) Antibody (#ARR-022).4-6. Anti-RAMP2 (extracellular) Antibody , preincubated with RAMP2 (extracellular) Blocking Peptide (#BLP-RR022).
Product Details
ARR-022-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)HPTEDSLLSKGKMED, corresponding to amino acid residues 54-68 of rat RAMP2, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTMUSP00000002615; OTTMUSP00000037624; receptor (calcitonin) activity modifying protein 2; receptor activity modifying protein 2 isoform; Receptor activity-modifying protein 2; RP23-281C18.6
Gene Aliases: Ramp2
UniProt ID: (Mouse) Q9WUP0, (Rat) Q9JHJ1
Entrez Gene ID: (Mouse) 54409, (Rat) 58966
angiogenesis
vasculogenesis
sprouting angiogenesis
cAMP biosynthetic process
transport
calcium ion transport
intracellular protein transport
signal transduction
G-protein coupled receptor signaling pathway
heart development
regulation of blood pressure
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of gene expression
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
adherens junction assembly
cellular response to vascular endothelial growth factor stimulus
negative regulation of vascular permeability
positive regulation of angiogenesis
bicellular tight junction assembly
basement membrane assembly
protein localization to plasma membrane
vascular smooth muscle cell development
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
response to hypoxia
female pregnancy
response to estradiol
response to progesterone
cellular response to hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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