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RANBP1 Antibody (PA5-21481) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of RANBP1 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: RANBP1 Polyclonal Antibody (Product # PA5-21481) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker. Blue: Hoechst 33342 staining.
产品信息
PA5-21481
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 201 of Ran BP1 (Uniprot ID#P43487)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11152109
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse brain.
Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (84%), Pig (96%), Chicken (91%), Rhesus Monkey (99%), Bovine (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HpaII tiny fragments locus 9A; HpaII tiny fragments locus 9a protein; Htf9-a/RanBP1; Ran-binding protein 1; Ran-specific GTPase-activating protein; RANBP1; RANG; testis secretory sperm-binding protein Li 221n
基因别名: Htf9-a; HTF9A; RANBP1
UniProt ID: (Human) P43487, (Mouse) P34022
Entrez Gene ID: (Human) 5902, (Mouse) 19385
G1/S transition of mitotic cell cycle
RNA export from nucleus
ubiquitin-dependent protein catabolic process
protein import into nucleus
spindle organization
signal transduction
viral process
positive regulation of GTPase activity
positive regulation of mitotic centrosome separation
cell-cell adhesion
positive regulation of neuron projection development
intracellular transport
cellular response to leptomycin B
