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RANBP10 Antibody (PA5-110267) in WB
Western blot analysis of RANBP10 in extracts of various cell lines. Samples were incubated with RANBP10 Polyclonal antibody (Product # PA5-110267) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-110267
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 362-497 of human RANBP10 (NP_065901.1).
偶联物
形式
Liquid
浓度
0.59 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855678
产品详细信息
Immunogen sequence: YPGSPSLSPR HGPSSSHMHN TGADSPSCSN GVASTKSKQN HSKYPAPSSS SSSSSSSSSS SPSSVNYSES NSTDSTKSQH HSSTSNQETS DSEMEMEAEH YPNGVLGSMS TRIVNGAYKH EDLQTDESSM DDRHPR
靶标信息
The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ran-binding protein 10; RanBP10; rangef
基因别名: 4432417N03Rik; KIAA1464; RANBP10
UniProt ID: (Human) Q6VN20, (Mouse) Q6VN19
Entrez Gene ID: (Human) 57610, (Mouse) 74334
