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产品信息
PA5-57978
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646305
产品详细信息
Immunogen sequence: PVFENVNVKS FDRCTGHSAE HTQCGKPQES TGRGSAFLKA VQGSGDTSRH CLPTLADAKG LQDTGGTVNY FWGIPFCPDG VDPNQYTKVI LCQLE
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 81%.
靶标信息
RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
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生物信息学
蛋白别名: BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1
基因别名: RAP80; RXRIP110; UIMC1; X2HRIP110
UniProt ID: (Human) Q96RL1
Entrez Gene ID: (Human) 51720
