Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 10
RAPGEF1 Antibody (MA5-26281) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human ovary tissue. To expose target proteins, 10mM citric buffer, pH6.0, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a RAPGEF1 monoclonal antibody (Product # MA5-26281).
产品信息
MA5-26281
产品规格
种属反应
Dog,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2C3
抗原
Full length human recombinant protein of RAPGEF1 produced in HEK293T cell
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2723554
靶标信息
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CRK SH3-binding GNRP; guanine nucleotide releasing factor 2; Guanine nucleotide-releasing factor 2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene); Protein C3G; Rap guanine nucleotide exchange factor (GEF) 1; Rap guanine nucleotide exchange factor 1
基因别名: 4932418O06Rik; C3G; C3G-1; C3G-2; GRF2; RAPGEF1
UniProt ID: (Human) Q13905
Entrez Gene ID: (Human) 2889, (Dog) 491286, (Rat) 63881, (Mouse) 107746
activation of MAPKK activity
blood vessel development
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of neuron projection development
single organismal cell-cell adhesion
Rap protein signal transduction
nerve growth factor signaling pathway
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
platelet-derived growth factor receptor signaling pathway
negative regulation of protein kinase B signaling
establishment of endothelial barrier
negative regulation of ERK1 and ERK2 cascade
cellular response to cAMP
negative regulation of canonical Wnt signaling pathway
regulation of cell junction assembly
cellular response to nerve growth factor stimulus
negative regulation of neural precursor cell proliferation
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of signal transduction
