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产品信息
PA1-29018
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide DHSVLTLQLPVTASVR, corresponding to amino acids 526-541 of Epac1.
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris glycine, pH 7.4-7.9, with 30% glycerol, 0.5% BSA
内含物
0.02% Sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2238215
产品详细信息
PA1-29018 detects Epac1 from human, rat, mouse samples.
靶标信息
Gene ontology (GO) annotation includes small GTPase mediated signal transduction. Target protein binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 9330170P05Rik; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI); EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
基因别名: 2310016P22Rik; 9330170P05Rik; bcm910; CAMP-GEFI; CGEF1; EPAC; EPAC1; HSU79275; RAPGEF3
UniProt ID: (Human) O95398, (Rat) Q9Z1C8, (Mouse) Q8VCC8
Entrez Gene ID: (Human) 10411, (Rat) 59326, (Mouse) 223864
angiogenesis
Rap protein signal transduction
positive regulation of peptidyl-serine phosphorylation
negative regulation of syncytium formation by plasma membrane fusion
positive regulation of GTPase activity
positive regulation of angiogenesis
regulation of protein kinase activity
positive regulation of protein export from nucleus
positive regulation of stress fiber assembly
positive regulation of syncytium formation by plasma membrane fusion
establishment of endothelial barrier
cellular response to cAMP
positive regulation of protein acetylation
regulation of actin cytoskeleton reorganization
regulation of histone H3-K9 acetylation
regulation of protein phosphorylation
positive regulation of protein phosphorylation
small GTPase mediated signal transduction
positive regulation of smooth muscle cell migration
positive regulation of ATPase activity
negative regulation of collagen biosynthetic process
intracellular signal transduction
positive regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
positive regulation of binding
positive regulation of calcium ion transport
negative regulation of cell death
positive regulation of actin cytoskeleton reorganization
signal transduction
brain development
cell proliferation
negative regulation of cardiac muscle cell apoptotic process
cAMP-mediated signaling
spinal cord development
positive regulation of cAMP catabolic process
response to nicotine
cellular response to drug
regulation of insulin secretion
artery development
cellular response to transforming growth factor beta stimulus
liver regeneration
positive regulation of GTP binding
positive regulation of calcium ion transmembrane transport
positive regulation of hydrogen:potassium-exchanging ATPase activity
cellular response to L-dopa
dorsal root ganglion development
