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产品信息
H00009771-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RAPGEF5 (AAH39203, 1 a.a. approximately 444 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MGSSRLRVFD PHLERKDSAA ALSDRELPLP TFDVPYFKYI DEEDEDDEWS SRSQSSTEDD SVDSLLSDRY VVVSGTPEKI LEHLLNDLHL EEVQDKETET LLDDFLLTYT VFMTTDDLCQ ALLRHYSAKK YQGKEENSDV PRRKRKVLHL VSQWIALYKD WLPEDEHSKM FLKTIYRNVL DDVYEYPILE KELKEFQKIL GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT EHSYVSVKAK VSSIAQEILL CSQLGKRVQL VKKFIKIAAH CKAQRNLNSF FAIVMGLNTA SVSRLSQTWE KIPGKFRKLF SELESLTDPS LNHKAYRDAF KKMKPPKIPF VPLLLKDVTF IHEGNKTFLD NLVNFEKLHM IADTVRTLRH CRTNQFGDLS PKEHQELKSY VNHLYVIDSQ QALFELSHRI EPRV
靶标信息
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Guanine nucleotide exchange factor for Rap1; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MR-GEF; Rap guanine nucleotide exchange factor (GEF) 5; Rap guanine nucleotide exchange factor 5; Related to Epac; Repac; tcag7.1034
基因别名: GFR; KIAA0277; MR-GEF; MRGEF; RAPGEF5; REPAC
UniProt ID: (Human) Q92565
Entrez Gene ID: (Human) 9771
