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RAR gamma-1,2 Antibody (PA5-121101) in WB
Western blot analysis of RAR gamma-1,2 in extracts of various cell lines. Samples were incubated with RAR gamma-1,2 Polyclonal antibody (Product # PA5-121101) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-121101
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 168-199 of human RARG (NP_0009571)
偶联物
形式
Liquid
浓度
1.82 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914673
产品详细信息
Positive test controls include: Mouse lung, Rat kidney. The target is usually found in the following locations: Nucleus.
Immunogen sequence: KKEVKEEGSP DSYELSPQLE ELITKVSKAH QE
靶标信息
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD. The corresponding gene for the retinoic acid receptor gamma 1 is NR1B3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nuclear receptor subfamily 1 group B member 3; RAR gamma 2; RAR-gamma; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor gamma; retinoic acid receptor gamma 4; retinoic acid receptor, gamma
基因别名: NR1B3; RAR-gamma; RARC; RARD; RARG; RARgamma2
UniProt ID: (Human) P13631, (Mouse) P18911
Entrez Gene ID: (Human) 5916, (Mouse) 19411, (Rat) 685072
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
protein binding
zinc ion binding
retinoid X receptor binding
sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
glandular epithelial cell development
retinal pigment epithelium development
growth plate cartilage chondrocyte growth
transcription initiation from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell size
anterior/posterior pattern specification
embryonic camera-type eye development
regulation of myelination
negative regulation of chondrocyte differentiation
response to retinoic acid
embryonic hindlimb morphogenesis
multicellular organism growth
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
steroid hormone mediated signaling pathway
regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic eye morphogenesis
retinoic acid receptor signaling pathway
canonical Wnt signaling pathway
face development
trachea cartilage development
prostate gland epithelium morphogenesis
Harderian gland development
cellular response to retinoic acid
chondrocyte development
growth plate cartilage development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of gene expression
positive regulation of gene expression
camera-type eye development
negative regulation of cell differentiation
reproductive structure development
gland development
retina development in camera-type eye
limb development
bone development
bone morphogenesis
epithelium development
negative regulation of cartilage development
