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Invitrogen
RARB Monoclonal Antibody (336)
FIGURE: 1 / 3
RARB Antibody (MA1-4670) in WB
Western blot was performed using Anti-RARB Monoclonal Antibody (336) (Product # MA1-4670) and 58, 37 kDa bands corresponding to RARB was observed across the cell lines tested and induced upon Retinoic acid treatment in Dendritic cells differentiated from THP-1. Whole cell lysates (30ug lysate) of THP-1 (Lane 1), THP-1 cells differentiated to Dendritic cells (Lane2), Dendritic cells treated with Retinoic acid (1uM for 24 hr) (Lane 3), A549 (Lane 4), SH-SY5Y (Lane 5), MCF7 (Lane 6) and IMR-32 (Lane 7) were electrophoresed using Novex® NuPAGE... View More
Product Details
MA1-4670
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
336
Immunogen
Synthetic peptide corresponding to the N-terminal region of human RARB conjugated to KLH
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_560887
Product Specific Information
This antibody is predicted to react with canine, guinea pig, mouse and non-human primate based on 100% sequence homology.
This antibody is specific for the ~48 kDa RXR-b protein.
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; RAR beta; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide
Gene Aliases: HAP; MCOPS12; NR1B2; RARB; RARbeta1; RRB2
UniProt ID: (Human) P10826
Entrez Gene ID: (Human) 5915, (Rat) 24706
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
drug binding
zinc ion binding
protein complex binding
retinoid X receptor binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
glandular epithelial cell development
outflow tract septum morphogenesis
retinal pigment epithelium development
growth plate cartilage development
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of cell proliferation
negative regulation of cell proliferation
striatum development
neurogenesis
regulation of myelination
negative regulation of chondrocyte differentiation
embryonic hindlimb morphogenesis
multicellular organism growth
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
steroid hormone mediated signaling pathway
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic eye morphogenesis
retinoic acid receptor signaling pathway
embryonic digestive tract development
ventricular cardiac muscle cell differentiation
retina development in camera-type eye
bone development
negative regulation of cartilage development
transcription initiation from RNA polymerase II promoter
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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