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产品信息
PA5-87944
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 598-797 of human RASGRP1 (NP_0057302)
偶联物
形式
Liquid
浓度
2.48 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804526
产品详细信息
Immunogen sequence: PVAPTENNTS VGPVSNLCSL GAKDLLHAPE EGPFTFPNGE AVEHGEESKD RTIMLMGVSS QKISLRLKRA VAHKATQTES QPWIGSEGPS GPFVLSSPRK TAQDTLYVLP SPTSPCPSPV LVRKRAFVKW ENKDSLIKSK EELRHLRLPT YQELEQEINT LKADNDALKI QLKYAQKKIE SLQLEKSNHV LAQMEQGDCS; Positive Samples: Jurkat, MCF7, A-549, U-251MG, SW480; Cellular Location: Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein, cytosol
靶标信息
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium and DAG-regulated guanine nucleotide exchange factor II; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II; CalDAG-GEF1; CalDAG-GEFII; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Ras guanyl-releasing protein; RAS guanyl-releasing protein 1
基因别名: CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; RASGRP1; V
UniProt ID: (Human) O95267, (Rat) Q9R1K8, (Mouse) Q9Z1S3
Entrez Gene ID: (Human) 10125, (Rat) 29434, (Mouse) 19419
phosphatidylserine binding
guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
calcium ion binding
zinc ion binding
lipid binding
diacylglycerol binding
phosphatidylcholine binding
protein homodimerization activity
Rap guanyl-nucleotide exchange factor activity
metal ion binding
guanyl-nucleotide exchange factor
MAPK cascade
cytokine production
positive regulation of protein phosphorylation
inflammatory response to antigenic stimulus
signal transduction
Ras protein signal transduction
regulation of phosphatidylinositol 3-kinase signaling
cell differentiation
secretory granule localization
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell differentiation
positive regulation of T cell differentiation in thymus
mast cell degranulation
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of JNK cascade
positive regulation of Ras protein signal transduction
vesicle transport along microtubule
protein oligomerization
regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
activation of GTPase activity
regulation of phospholipase C activity
regulation of p38MAPK cascade
positive regulation of interferon-gamma secretion
small GTPase mediated signal transduction
intracellular signal transduction
regulation of GTPase activity
