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RASGRP3 Antibody (PA5-106371) in ICC/IF
Immunofluorescent analysis of RASGRP3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and RASGRP3 polyclonal antibody (Product # PA5-106371) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-106371
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RASGRP3(Accession Q8IV61), corresponding to amino acid residues T361-K411.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854046
产品详细信息
Antibody detects endogenous levels of total RASGRP3.
靶标信息
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium and DAG-regulated guanine nucleotide exchange factor III; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III; CalDAG-GEFIII; Guanine nucleotide exchange factor for Rap1; OTTHUMP00000201245; RAS guanyl releasing protein 3 (calcium and DAG-regulated); Ras guanyl-releasing protein 3; RAS, guanyl releasing protein 3
基因别名: GRP3; KIAA0846; RASGRP3
UniProt ID: (Human) Q8IV61
Entrez Gene ID: (Human) 25780, (Rat) 313874
signal transducer activity
guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
GTPase activator activity
calcium ion binding
protein binding
Ras GTPase binding
kinase binding
diacylglycerol binding
molecular_function
metal ion binding
guanyl-nucleotide exchange factor
