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产品信息
MA5-25425
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2B11
抗原
Full length human recombinant protein of RASSF1 produced in E.coli
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2723563
靶标信息
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiac-specific ras association domain family 1 protein; pancreas-specific ras association domain family 1 protein; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain-containing protein 1; RASSF1; tumor suppressor protein RDA32; WUGSC:H_LUCA12.5
基因别名: 123F2; NORE2A; RASSF1; RASSF1A; RDA32; REH3P21
UniProt ID: (Human) Q9NS23
Entrez Gene ID: (Human) 11186
