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产品信息
H00064783-B01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RBM15 (AAI03661.1, 1 a.a. approximately 544 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSHRAKLAMS GKIIIRNPIK IGYGKATPTT RLWVGGLGPW VPLAALAREF DRFGTIRTID YRKGDSWAYI QYESLDAAHA AWTHMRGFPL GGPDRRLRVD FADTEHRYQQ QYLQPLPLTH YELVTDAFGH RAPDPLRGAR DRTPPLLYRD RDRDLYPDSD WVPPPPPVRE RSTRTAATSV PAYEPLDSLD RRRDGWSLDR DRGDRDLPSS RDQPRKRRLP EESGGRHLDR SPESDRPRKR HCAPSPDRSP ELSSSRDRYN SDNDRSSRLL LERPSPIRDR RGSLEKSQGD KRDRKNSASA ERDRKHRTTA PTEGKSPLKK EDRSDGSAPS TSTASSKLKS PSQKQDGGTA PVASASPKLC LAWQGMLLLK NSNFPSNMHL LQGDLQVASS LLVEGSTGGK VAQLKITQRL RLDQPKLDEV TRRIKVAGPN GYAILLAVPG SSDSRSSSSS AASDTATSTQ RPLRNLVSYL KQKQAAGVIS LPVGGNKDKE NTGVLHAFPP CEFSQQFLDS PAKALAKSEE DYLVMIIVRA KLVEQRMKIW NSKL
靶标信息
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: one twenty two protein; one twenty-two; One-twenty two protein 1; RNA binding motif protein 15; RNA-binding motif protein 15; RNA-binding protein 15
基因别名: OTT; OTT1; RBM15; SPEN
UniProt ID: (Human) Q5T613
Entrez Gene ID: (Human) 64783, (Rat) 684233
mRNA splicing, via spliceosome
patterning of blood vessels
positive regulation of transcription of Notch receptor target
viral process
negative regulation of myeloid cell differentiation
negative regulation of transcription, DNA-templated
spleen development
ventricular septum morphogenesis
placenta blood vessel development
negative regulation of transcription from RNA polymerase II promoter
