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RBM15 Antibody (PA5-92321) in IHC (P)
Immunohistochemistry analysis of RBM15 in paraffin-embedded human colon carcinoma. Samples were incubated with RBM15 Polyclonal antibody (Product # PA5-92321) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-92321
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_0011884741)
偶联物
形式
Liquid
浓度
0.38 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806439
产品详细信息
Immunogen sequence: EHRYQQQYLQ PLPLTHYELV TDAFGHRAPD PLRGARDRTP PLLYRDRDRD LYPDSDWVPP PPPVRERSTR TAATSVPAYE PLDSLDRRRD GWSLDRDRGD RDLPSSRDQP RKRRLPEESG GRHLDRSPES DRPRKRHCAP SPDRSPELSS SRDRYNSDND RSSRLLLERP SPIRDRRGSL EKSQGDKRDR KNSASAERDR KHRTTAPTEG KSPLKKEDRS DGSAPSTSTA SSKLKSPSQK QDGGTAPVAS A; Positive Samples: HL-60, HepG2, 293T, Jurkat, Mouse thymus, Mouse spleen; Cellular Location: Nucleus, Nucleus membrane, Nucleus speckle, Peripheral membrane protein, nucleoplasm
靶标信息
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: one twenty two protein; one twenty-two; One-twenty two protein 1; putative RNA-binding protein 15; RNA-binding motif protein 15; RNA-binding protein 15
基因别名: C230088J01Rik; Kiaa4257; mKIAA1438; OTT; OTT1; RBM15; SPEN
UniProt ID: (Human) Q5T613, (Mouse) Q0VBL3
Entrez Gene ID: (Human) 64783, (Mouse) 229700
mRNA splicing, via spliceosome
patterning of blood vessels
positive regulation of transcription of Notch receptor target
viral process
negative regulation of myeloid cell differentiation
negative regulation of transcription, DNA-templated
spleen development
ventricular septum morphogenesis
placenta blood vessel development
negative regulation of transcription from RNA polymerase II promoter
