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产品信息
PA5-34519
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide near the carboxy terminus of human RC3H1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551871
产品详细信息
A suggested positive control is Hela cell lysate.
PA5-34519 can be used with blocking peptide PEP-1562.
靶标信息
The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: probable E3 ubiquitin-protein ligase Roquin; Protein Sanroque; RING CCCH (C3H) domains 1; RING finger and C3H zinc finger protein 1; ring finger and CCCH-type domains 1; RING finger and CCCH-type zinc finger domain-containing protein 1; ring finger and CCCH-type zinc finger domains 1; RING finger protein 198; Roquin; Roquin-1
基因别名: 5730557L09Rik; Gm551; KIAA2025; mKIAA2025; N28103; RC3H1; RGD1563512; RNF198; ROQUIN
UniProt ID: (Human) Q5TC82, (Mouse) Q4VGL6
Entrez Gene ID: (Human) 149041, (Rat) 680586, (Mouse) 381305
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA catabolic process
B cell homeostasis
regulation of germinal center formation
negative regulation of germinal center formation
posttranscriptional regulation of gene expression
protein ubiquitination
negative regulation of B cell proliferation
cytoplasmic mRNA processing body assembly
T cell proliferation
T cell homeostasis
regulation of mRNA stability
negative regulation of T-helper cell differentiation
negative regulation of activated T cell proliferation
lymph node development
spleen development
regulation of T cell receptor signaling pathway
positive regulation of mRNA catabolic process
3'-UTR-mediated mRNA destabilization
T follicular helper cell differentiation
cellular response to interleukin-1
positive regulation of NIK/NF-kappaB signaling
regulation of gene expression
