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RCAN1 Antibody (PA5-142673) in ICC/IF
Immunocytochemistry analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Samples were incubated with RCAN1 polyclonal antibody (Product # PA5-142673) using a dilution of 10 µg/mL for 1 hr followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
Product Details
PA5-142673
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-HIGSSHLAPPNPD.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933319
Product Specific Information
Additional Information: This antibody is expected to recognize all three reported isoforms (NP_004405.3; NP_981962.1; NP_981963.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcineurin inhibitor; Calcipressin-1; Down syndrome critical region protein 1 homolog; MCIP1; Myocyte-enriched calcineurin-interacting protein 1; Regulator of calcineurin 1
Gene Aliases: Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; Rcan1; RCN1
UniProt ID: (Mouse) Q9JHG6
Entrez Gene ID: (Mouse) 54720
response to ischemia
response to stress
response to oxidative stress
short-term memory
calcium-mediated signaling
locomotion involved in locomotory behavior
calcineurin-NFAT signaling cascade
regulation of phosphoprotein phosphatase activity
skeletal muscle fiber development
regulation of catalytic activity
regulation of calcineurin-NFAT signaling cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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