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产品信息
IHC-00201
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residues 475 and the C-terminus (residue 529) of Human RAG cohort 1 (Karyopherin Alpha 2).
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan and Chimpanzee
靶标信息
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IMA2; importin alpha 2; Importin alpha P1; Importin subunit alpha-1; importin subunit alpha-2; importin-alpha-P1; IPOA 1; IPOA1 QIP2; Karyopherin A2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Karyopherin subunit alpha-2; m-importin-alpha-P1; Pendulin; Pore targeting complex 58 kDa subunit; PTAC58; RAG cohort 1; RAG cohort protein 1; RCH 1; SRP 1; SRP1 alpha; SRP1-alpha
基因别名: 2410044B12Rik; IPOA1; KPNA2; PTAC58; QIP2; RCH1; SRP1; SRP1-alpha; SRP1alpha
UniProt ID: (Human) P52292, (Mouse) P52293
Entrez Gene ID: (Human) 3838, (Mouse) 16647
