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Immunogen sequence: KPTVRKERVV RPDSELGERP PEDNQSFQYD HEAFLGKEDS KTFDQLTPDE SKERLGKIVD RIDNDGDGFV TTEELKTWIK RVQKRYIFDN VAKVWKDYDR DKDDKISWEE YKQATYGYYL GNPAEFHDSS DHHTFKKMLP RDERRFKAAD LNGDLTATRE EFTAFLHPEE FEHMKEIVVL ETLEDIDKNG DGFVDQDEYI ADMFSHEENG PEPDWVLSER EQFNEFRDLN KDGKLDKDEI RHWILPQDYD HAQAEARHLV YESDKNKDEK LTKEEILENW NMFVGSQATN YGEDLTKNHD EL; Positive Samples: A-549, SKOV3, LO2, HeLa; Cellular Location: Endoplasmic reticulum lumen
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis secretory protein Li 84; FLJ37041; proliferation-inducing gene 20; reticulocalbin 1, EF-hand calcium binding domain; Reticulocalbin-1
基因别名: HEL-S-84; PIG20; Rca1; RCAL; RCN; RCN1
UniProt ID: (Human) Q15293, (Mouse) Q05186
Entrez Gene ID: (Human) 5954, (Mouse) 19672