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产品信息
PA5-37388
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length human RFC1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2554041
产品详细信息
This antibody detects endogenous protein at a molecular weight of 140 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide binding consensus sequences. Four of the five RFC genes (RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC2, the third-largest subunit of the RFC complex, exhibits ATP binding which makes it important for both DNA replication and checkpoint function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A1 140 kDa subunit; A1-P145; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; Differentiation-specific element-binding protein; DNA-binding protein PO-GA; ISRE-binding protein; MHC binding factor, beta; replication factor C (activator 1) 1, 145kDa; replication factor C 1; Replication factor C 140 kDa subunit; Replication factor C large subunit; Replication factor C subunit 1; replication factor C, 140 kDa; replication factor C1; RF-C 140 kDa subunit
基因别名: 140kDa; A1; Alp145; Ibf-1; MHCBFB; PO-GA; RECC1; RFC; RFC1; RFC140
UniProt ID: (Human) P35251, (Mouse) P35601
Entrez Gene ID: (Human) 5981, (Rat) 89809, (Mouse) 19687
telomere maintenance via recombination
DNA-dependent DNA replication
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, DNA gap filling
transcription, DNA-templated
regulation of transcription, DNA-templated
telomere maintenance via telomerase
translesion synthesis
nucleotide-excision repair, DNA incision
error-prone translesion synthesis
DNA damage response, detection of DNA damage
positive regulation of catalytic activity
error-free translesion synthesis
negative regulation of transcription from RNA polymerase II promoter
DNA replication
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
DNA repair
