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RGMC Polyclonal Antibody

RGMC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RGMC Antibody (OSR00358W-100UL) in IHC (P)

IHC-P on paraffin sections of rat lung. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. P... View More

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产品信息

OSR00358W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:2,000

免疫组化（石蜡） (IHC (P))

1:1,000

其他PubMed (Misc)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from c-terminal region of mature human Repulsive guidance molecule C (RGMC, Hemojuvelin) conjugated to an immunogenic carrier protein was used as the antigen

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: RGMC.

靶标信息

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

Nature genetics

Babitt JL,Huang FW,Wrighting DM,Xia Y,Sidis Y,Samad TA,Campagna JA,Chung RT,Schneyer AL,Woolf CJ,Andrews NC,Lin HY

Mon May 01 00:00:00 UTC 2006

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nature genetics

Ota T,Suzuki Y,Nishikawa T,Otsuki T,Sugiyama T,Irie R,Wakamatsu A,Hayashi K,Sato H,Nagai K,Kimura K,Makita H,Sekine M,Obayashi M,Nishi T,Shibahara T,Tanaka T,Ishii S,Yamamoto J,Saito K,Kawai Y,Isono Y,Nakamura Y,Nagahari K,Murakami K,Yasuda T,Iwayanagi T,Wagatsuma M,Shiratori A,Sudo H,Hosoiri T,Kaku Y,Kodaira H,Kondo H,Sugawara M,Takahashi M,Kanda K,Yokoi T,Furuya T,Kikkawa E,Omura Y,Abe K,Kamihara K,Katsuta N,Sato K,Tanikawa M,Yamazaki M,Ninomiya K,Ishibashi T,Yamashita H,Murakawa K,Fujimori K,Tanai H,Kimata M,Watanabe M,Hiraoka S,Chiba Y,Ishida S,Ono Y,Takiguchi S,Watanabe S,Yosida M,Hotuta T,Kusano J,Kanehori K,Takahashi-Fujii A,Hara H,Tanase TO,Nomura Y,Togiya S,Komai F,Hara R,Takeuchi K,Arita M,Imose N,Musashino K,Yuuki H,Oshima A,Sasaki N,Aotsuka S,Yoshikawa Y,Matsunawa H,Ichihara T,Shiohata N,Sano S,Moriya S,Momiyama H,Satoh N,Takami S,Terashima Y,Suzuki O,Nakagawa S,Senoh A,Mizoguchi H,Goto Y,Shimizu F,Wakebe H,Hishigaki H,Watanabe T,Sugiyama A,Takemoto M,Kawakami B,Yamazaki M,Watanabe K,Kumagai A,Itakura S,Fukuzumi Y,Fujimori Y,Komiyama M,Tashiro H,Tanigami A,Fujiwara T,Ono T,Yamada K,Fujii Y,Ozaki K,Hirao M,Ohmori Y,Kawabata A,Hikiji T,Kobatake N,Inagaki H,Ikema Y,Okamoto S,Okitani R,Kawakami T,Noguchi S,Itoh T,Shigeta K,Senba T,Matsumura K,Nakajima Y,Mizuno T,Morinaga M,Sasaki M,Togashi T,Oyama M,Hata H,Watanabe M,Komatsu T,Mizushima-Sugano J,Satoh T,Shirai Y,Takahashi Y,Nakagawa K,Okumura K,Nagase T,Nomura N,Kikuchi H,Masuho Y,Yamashita R,Nakai K,Yada T,Nakamura Y,Ohara O,Isogai T,Sugano S

Thu Jan 01 00:00:00 UTC 2004

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.

Nature genetics

Papanikolaou G,Samuels ME,Ludwig EH,MacDonald ML,Franchini PL,Dubé MP,Andres L,MacFarlane J,Sakellaropoulos N,Politou M,Nemeth E,Thompson J,Risler JK,Zaborowska C,Babakaiff R,Radomski CC,Pape TD,Davidas O,Christakis J,Brissot P,Lockitch G,Ganz T,Hayden MR,Goldberg YP

Thu Jan 01 00:00:00 UTC 2004

生物信息学

蛋白别名: DL M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile) (human homolog); Hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; Hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; MGC23953; OTTHUMP00000059680; repulsive guidance molecule C; RGM C; RGM domain family member C

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基因别名: 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL-M; hemojuvelin; HFE2; HFE2A; HJV; JH; RGMC

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UniProt ID: (Human) Q6ZVN8, (Mouse) Q7TQ32

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Entrez Gene ID: (Human) 148738, (Rat) 310681, (Mouse) 69585

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功能

glycoprotein binding receptor binding protein binding coreceptor activity BMP binding BMP receptor activity transferrin receptor binding molecular_function

参与通路