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产品信息
MA5-47078
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1522
抗原
Recombinant protein encompassing a sequence within the center region of human RGS4. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938150
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC2124; MGC60244; Regulator of G-protein signaling 4; RGP4; RGS4; RP11-430G6.1; schizophrenia disorder 9
基因别名: AA004315; AA597169; ESTM48; ESTM50; RGP4; RGS4; SCZD9
UniProt ID: (Human) P49798, (Mouse) O08899, (Rat) P49799
Entrez Gene ID: (Human) 5999, (Mouse) 19736, (Rat) 29480
inactivation of MAPK activity
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of GTPase activity
negative regulation of G-protein coupled receptor protein signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of signal transduction
termination of G-protein coupled receptor signaling pathway
