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产品信息
PA5-20862
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 13 amino acid peptide from near the center of human RHBDD3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11157850
产品详细信息
A suggested positive control is rat lung tissue lysate.
PA5-20862 can be used with blocking peptide PEP-0976.
靶标信息
The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTA-984G1.4; pituitary tumor apoptosis; pituitary-derived proapoptotic; Rhomboid domain-containing protein 3
基因别名: C22orf3; HS984G1A; PTAG; RGD1311827; RHBDD3
UniProt ID: (Human) Q9Y3P4, (Mouse) Q8BP97, (Rat) Q642B3
Entrez Gene ID: (Human) 25807, (Mouse) 279766, (Rat) 289753
