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RHD Antibody (PA5-90215) in WB
Western blot analysis of RHD in extracts of various cell lines. Samples were incubated with RHD Polyclonal antibody (Product # PA5-90215) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
产品信息
PA5-90215
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human RHD (NP_0011211631)
偶联物
形式
Liquid
浓度
2.4 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805964
产品详细信息
Immunogen sequence: LGNLRMVISN IFNTDYHMNM MHIYVFAAYF GLSVAWCLPK PLPEGTEDKD QTATIPSLSA MLGALFLWMF WPSFNSALLR SPIERKNAVF NTYYAVAVSV V; Positive Samples: U-251MG, LO2, rat spleen, rat liver; Cellular Location: Membrane, Multi-pass membrane protein
靶标信息
The Rhesus (Rh) blood group system represents one of the most complex and important systems in humans. Two highly homologous genes RHD and RHCE (collectively referred to as RH30 or RHCED) encode the antigens of the Rh blood group system (1-4). These tightly linked genes map to human chromosomal position 1p34.1-1p36. The RHD gene, which is commonly deleted from a large segment of the population, encodes the most potent blood group immunogen, the D antigen (2,5). Rh incompatibility between maternal and fetal blood types results in hemolytic disease of the newborn (HDN), which often results in fetal death (1,2,6). The RHCE gene exists in four allelic forms, and each allele determines the expression of two antigens in Ce, ce, cE, or CE combinations (2,4,5). The RHCED antigens exist as integral membrane proteins with contain 12-transmembrane helices, and maintain erythrocyte membrane integrity. The presentation of the Rh antigenic activity requires the formation of a complex between the RHCED antigens and RHAG (RH50).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: blood group antigen D; blood group protein RHD; Blood group Rh(D) polypeptide; CD240D; D antigen (DCS); Erythrocyte membrane glycoprotein Rh30; Rh blood group antigen Evans; Rh blood group, D anitgen; Rh blood group, D antigen; RH polypeptide 2; RhD blood group antigen; RhD polypeptide; Rhesus blood group CE and D; Rhesus blood group D antigen allele DIII type 7; Rhesus D antigen; Rhesus system D polypeptide; RhPII; RHXIII; truncated rhesus blood group D antigen; truncated rhesus D
基因别名: CD240D; DIIIc; RH; RH30; Rh4; RHCED; RHD; RhDCw; RHDel; RHDVA(TT); RhII; RhK562-II; RhPI; RHPII; RHXIII
UniProt ID: (Human) Q02161, (Rat) O88298
Entrez Gene ID: (Human) 6007, (Rat) 60414
