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RIM1 Antibody (PA5-117424) in WB
Western blot analysis of RIM1 in Various tissue extracts (50 µg). Samples were separated with 5% SDS-PAGE and incubated in RIM1 polyclonal antibody (Product # PA5-117424) using a dilution of 1:500, followed by HRP-conjugated anti-rabbit IgG. Detection was performed with Trident ECL plus-Enhanced.
产品信息
PA5-117424
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of mouse RIM1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
4.11 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2902054
产品详细信息
Centrifuge briefly prior to opening.
靶标信息
Rims1 is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. Rims1 also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations in the Rims1 gene have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Further, Rims1 may act as scaffold protein that regulates neurotransmitter release at the active zone. Rims1 may also be essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Rims1 also plays a role in dendrite formation by melanocytes. Multiple transcript variants encoding different isoforms have been described for this Rims1. Diseases associated with RIMS1 include Cone-Rod Dystrophy 7 and Retinitis Pigmentosa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Rab-3-interacting molecule 1; Rab-3-interacting protein 1; Rab3 effector; Rab3 interacting protein 1; rab3-interacting molecule 1; rab3-interacting protein 1; regulating synaptic membrane exocytosis 1 beta; Regulating synaptic membrane exocytosis protein 1; RIM 1; Rim1b protein; synaptic exocytosis regulator 1
基因别名: C030033M19Rik; Kiaa0340; mKIAA0340; Rab3ip1; Rim; RIM1; RIM1a; RIM1alpha; Rims1; Serg1
UniProt ID: (Mouse) Q99NE5, (Rat) Q9JIR4
Entrez Gene ID: (Mouse) 116837, (Rat) 84556
protein complex assembly
transport
neurotransmitter transport
intracellular protein transport
exocytosis
positive regulation of gene expression
positive regulation of synaptic vesicle priming
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
calcium ion-regulated exocytosis of neurotransmitter
long-term synaptic potentiation
spontaneous neurotransmitter secretion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
regulation of synaptic vesicle exocytosis
positive regulation of excitatory postsynaptic potential
positive regulation of synaptic vesicle fusion to presynaptic membrane
