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产品信息
PA5-84724
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human RIMS2. Recombinant protein control fragment (Product #RP-107501).
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2791875
产品详细信息
Immunogen sequence: MDIEERNRQM KINKYKQVAG SDPRLEQDYH SKYRSGWDPH RGADNVSTKS S
靶标信息
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; RAB3 interacting protein 3; rab3-interacting molecule 2; Rab3-interacting protein; Regulating synaptic membrane exocytosis protein 2; RIM 2; RIM2 (CT)
基因别名: KIAA0751; OBOE; RAB3IP3; RIM2; RIMS2
UniProt ID: (Human) Q9UQ26
Entrez Gene ID: (Human) 9699
intracellular protein transport
positive regulation of gene expression
calcium ion regulated exocytosis
regulation of exocytosis
cAMP-mediated signaling
insulin secretion
regulation of membrane potential
calcium ion-regulated exocytosis of neurotransmitter
spontaneous neurotransmitter secretion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
positive regulation of excitatory postsynaptic potential
