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产品信息
PA5-101812
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RIN1(Accession Q13671), corresponding to amino acid residues T654-A704.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851244
产品详细信息
Antibody detects endogenous levels of total RIN1.
靶标信息
Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ras and Rab interactor 1; ras inhibitor; ras inhibitor 1; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIBA; RIT2; ROC2
基因别名: RIN1
UniProt ID: (Human) Q13671, (Rat) P97680, (Mouse) Q921Q7
Entrez Gene ID: (Human) 9610, (Rat) 207119, (Mouse) 225870
