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产品信息
PA5-29626
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 6 and 250 of Human RIP2
偶联物
形式
Liquid
浓度
0.88 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547101
产品详细信息
Recommended positive controls: NIH-3T3.
Predicted reactivity: Mouse (95%), Rat (95%), Chicken (80%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
RIPK2 is a serine/threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; EC 2.7.11.1; growth-in; growth-inhibiting gene 30; kinase RIPK2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RIP 2; RIP-2; RIP-like; RIP-like-interacting CLARP kinase; Tyrosine-protein kinase RIPK2; WUGSC:H_RG437L15.1
基因别名: 2210420D18Rik; CARD3; CARDIAK; CCK; D4Bwg0615e; GIG30; RICK; RIP2; RIPK2; UNQ277/PRO314/PRO34092
UniProt ID: (Human) O43353, (Mouse) P58801
Entrez Gene ID: (Human) 8767, (Mouse) 192656
protein serine/threonine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
receptor binding
protein binding
ATP binding
LIM domain binding
protein homodimerization activity
CARD domain binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPK activity
positive regulation of cytokine-mediated signaling pathway
adaptive immune response
apoptotic process
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
JNK cascade
positive regulation of peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of immature T cell proliferation
positive regulation of peptidyl-serine phosphorylation
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
T cell proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
innate immune response
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of alpha-beta T cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-positive bacterium
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-binding oligomerization domain containing 1 signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
response to interleukin-1
response to interleukin-12
response to interleukin-18
cellular response to lipoteichoic acid
cellular response to peptidoglycan
cellular response to muramyl dipeptide
positive regulation of xenophagy
immune system process
positive regulation of T-helper 1 type immune response
protein phosphorylation
phosphorylation
positive regulation of stress-activated MAPK cascade
regulation of apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to lipopolysaccharide
