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产品信息
PA5-29530
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 283 and 579 of Human RNF12
偶联物
形式
Liquid
浓度
0.66 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547006
产品详细信息
Recommended positive controls: Jurkat, Raji, K562.
Predicted reactivity: Rat (80%), Rhesus Monkey (99%), Bovine (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
RNF12 is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTD-2530H13.3; DKFZp686N06224; E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase RNF12; FLJ25923; FLJ41093; FLJ42887; FLJ45986; LIM domain-interacting RING finger protein; MGC15161; R-LIM; Renal carcinoma antigen NY-REN-43; RING finger LIM domain-binding protein; RING finger protein 12; ring zinc finger LIM domain binding protein; ring zinc finger protein NY-REN-43antigen; RING-type E3 ubiquitin transferase RLIM
基因别名: NY-REN-43; RLIM; RNF12
UniProt ID: (Human) Q9NVW2
Entrez Gene ID: (Human) 51132
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
transcription, DNA-templated
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
random inactivation of X chromosome
regulation of dosage compensation by inactivation of X chromosome
