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产品信息
PA5-18148
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (HTGAAAEEFNDDT) corresponding to the C-terminus amino acids of RNF139 (aa 651-664).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10989810
产品详细信息
This antibody is predicted to react with canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a ttranslocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase RNF139; MGC31961; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; RING finger protein 139; RING-type E3 ubiquitin transferase RNF139; RNF139; Translocation in renal carcinoma on chromosome 8 protein
基因别名: HRCA1; RCA1; RNF139; TRC8
UniProt ID: (Human) Q8WU17
Entrez Gene ID: (Human) 11236
protein polyubiquitination
negative regulation of cell proliferation
protein ubiquitination
negative regulation of translation
regulation of protein ubiquitination
protein destabilization
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of ER to Golgi vesicle-mediated transport
regulation of protein processing
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
