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产品信息
PA5-66164
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664117
产品详细信息
Immunogen sequence: KAKVTTMTPAS NPIIGVLLST QNNRCVSAPD LTIEKRLPFS SLSSLASLHK PERSVSPESN DSISEELNHF KPIVCSPCTP PKRLPDGRVL SPLIIKSTPR NLN
Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.
靶标信息
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169
基因别名: KIAA1991; RNF169
UniProt ID: (Human) Q8NCN4
Entrez Gene ID: (Human) 254225
