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产品信息
PA5-67332
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human RNF34. Recombinant protein control fragment (Product #RP-105587).
偶联物
形式
Liquid
浓度
0.16 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664319
产品详细信息
Immunogen sequence: NIVCKACGLSF SVFRKKHVCC DCKKDFCSVC SVLQENLRRC STCHLLQETA FQRPQLMRLK VKDL
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 97%.
靶标信息
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CARP-1; Caspase regulator CARP1; Caspases-8 and -10-associated RING finger protein 1; E3 ubiquitin-protein ligase RNF34; FLJ21786; FYVE-RING finger protein MOMO; hRFI; Human RING finger homologous to inhibitor of apoptosis protein; RING finger protein 34; ring finger protein 34, E3 ubiquitin protein ligase; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34
基因别名: CARP-1; CARP1; hRFI; RFI; RIF; RIFF; RNF34
UniProt ID: (Human) Q969K3
Entrez Gene ID: (Human) 80196
protein polyubiquitination
apoptotic process
protein ubiquitination
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular response to cold
protein K48-linked ubiquitination
negative regulation of signal transduction by p53 class mediator
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of oxygen metabolic process
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
