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产品信息
PA5-61941
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646677
产品详细信息
Immunogen sequence: HNDSVVIVDE RRRPRRNARR LPQDHADSCV VSSDDEELSR DRDVYVTTHT PRNARDEGAT
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 85%.
靶标信息
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
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生物信息学
蛋白别名: E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; Protein SNURF; RING finger protein 4; Small nuclear ring finger protein
基因别名: RES4-26; RNF4; SLX5; SNURF
UniProt ID: (Human) P78317
Entrez Gene ID: (Human) 6047
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
transcription factor binding
zinc ion binding
ligase activity
nucleosome binding
SUMO polymer binding
identical protein binding
androgen receptor binding
ubiquitin protein ligase activity
transcription, DNA-templated
protein ubiquitination
androgen receptor signaling pathway
negative regulation of protein sumoylation
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to arsenic-containing substance
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein K6-linked ubiquitination
regulation of spindle assembly
regulation of kinetochore assembly
