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RNaseL Antibody (MA5-50495) in WB
Western Blot analysis of RNaseL using RNaseL Recombinant Monoclonal Antibody (Product # MA5-50495) in K562 (30 μg), THP-1 (30 μg), and HL-60 (30 μg) whole cell extracts at a dilution of 1:1,000. Extracts were separated by 7.5% SDS-PAGE. An HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA5-50495
产品规格
种属反应
Dog,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2341
抗原
Recombinant fragment of human RNase L.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3093935
靶标信息
A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNAase; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2 5-oligoisoadenylate synthetase-dependent); ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent); RNase L
基因别名: E230029I04Rik; PRCA1; RNASEL; RNS4
UniProt ID: (Human) Q05823, (Mouse) Q05921
Entrez Gene ID: (Human) 6041, (Dog) 490310, (Mouse) 24014, (Rat) 359726
RNA binding
endoribonuclease activity
protein kinase activity
protein binding
ATP binding
rRNA binding
ribonucleoprotein complex binding
metal ion binding
nucleotide binding
nuclease activity
endonuclease activity
ribonuclease activity
bidentate ribonuclease III activity
transferase activity, transferring phosphorus-containing groups
hydrolase activity
rRNA processing
mRNA processing
protein phosphorylation
regulation of mRNA stability
negative regulation of viral genome replication
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
RNA phosphodiester bond hydrolysis
positive regulation of glucose import in response to insulin stimulus
transmembrane transport
type I interferon signaling pathway
RNA phosphodiester bond hydrolysis, endonucleolytic
