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产品信息
MA5-15441
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1B5A9
抗原
Purified recombinant fragment of human RON (aa210-320) expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10984254
产品详细信息
MA5-15441 targets RON in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15441 immunogen is purified recombinant fragment of human RON (aa210-320) expressed in E. Coli.
MA5-15441 detects RON which has a predicted molecular weight of approximately 152kDa.
靶标信息
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
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生物信息学
蛋白别名: c-met-related tyrosine kinase; CD136; CDw136; Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; MST1R variant RON30; MST1R variant RON62; p185-Ron; Protein-tyrosine kinase 8; PTK8 protein tyrosine kinase 8; RON variant E2E3
基因别名: CD136; CDw136; MST1R; PTK8; RON
UniProt ID: (Human) Q04912
Entrez Gene ID: (Human) 4486
movement of cell or subcellular component
defense response
signal transduction
single fertilization
positive regulation of cell proliferation
response to virus
peptidyl-tyrosine phosphorylation
macrophage colony-stimulating factor signaling pathway
positive regulation of MAP kinase activity
innate immune response
hepatocyte growth factor receptor signaling pathway
positive regulation of protein kinase B signaling
