Invitrogen

ROR gamma Polyclonal Antibody

ROR gamma Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ROR gamma Antibody (PA5-23148) in IHC (P)

Immunohistochemical analysis of ROR gamma in Tissue section of human lymph node. Samples were incubated in ROR gamma polyclonal antibody (Product # PA5-23148) followed by a HRP labeled secondary antibody and DAB reagent. Nuclei of cells were counter-stained with hematoxylin. This antibody generated mainly a nuclear staining in a subset of cells and a weak to cytoplasmic staining was also observed in some ce... View More

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产品信息

PA5-23148

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

10 µg/mL

免疫组化（冰冻） (IHC (F))

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免疫细胞化学 (ICC/IF)

Assay-Dependent

免疫沉淀 (IP)

Assay-Dependent

产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A portion of amino acids 1-50 of human ROR gamma/RORC/NR1F3

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2540675

靶标信息

ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

VX-765 reduces neuroinflammation after spinal cord injury in mice.

Neural regeneration research

Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ

PA5-23148 was used in Immunohistochemistry to suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.

Wed Sep 01 00:00:00 UTC 2021

Boosting Akt Pathway by Rupatadine Modulates Th17/Tregs Balance for Attenuation of Isoproterenol-Induced Heart Failure in Rats.

Frontiers in pharmacology

Ahmed LA,Mohamed AF,Abd El-Haleim EA,El-Tanbouly DM

PA5-23148 was used in Western Blot to assess the possible protection afforded by rupatadine against isoproterenol-induced heart failure in rats.

Tue May 18 00:00:00 UTC 2021

Boosting Akt Pathway by Rupatadine Modulates Th17/Tregs Balance for Attenuation of Isoproterenol-Induced Heart Failure in Rats.

Frontiers in pharmacology

Ahmed LA,Mohamed AF,Abd El-Haleim EA,El-Tanbouly DM

PA5-23148 was used in Western Blot to assess the possible protection afforded by rupatadine against isoproterenol-induced heart failure in rats.

Tue May 18 00:00:00 UTC 2021

Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas.

Cancer research

Lenkiewicz E,Malasi S,Hogenson TL,Flores LF,Barham W,Phillips WJ,Roesler AS,Chambers KR,Rajbhandari N,Hayashi A,Antal CE,Downes M,Grandgenett PM,Hollingsworth MA,Cridebring D,Xiong Y,Lee JH,Ye Z,Yan H,Hernandez MC,Leiting JL,Evans RM,Ordog T,Truty MJ,Borad MJ,Reya T,Von Hoff DD,Fernandez-Zapico ME,Barrett MT

PA5-23148 was used in Immunohistochemistry to provide a unique description of the ASCP genomic and epigenomic landscape and identify candidate therapeutic targets for this dismal cancer.

Thu Oct 15 00:00:00 UTC 2020

CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.

Journal of neuroinflammation

Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ

PA5-23148 was used in Immunohistochemistry (Frozen) to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.

Sat Aug 29 00:00:00 UTC 2020

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.

Cell

Lytle NK,Ferguson LP,Rajbhandari N,Gilroy K,Fox RG,Deshpande A,Schürch CM,Hamilton M,Robertson N,Lin W,Noel P,Wartenberg M,Zlobec I,Eichmann M,Galván JA,Karamitopoulou E,Gilderman T,Esparza LA,Shima Y,Spahn P,French R,Lewis NE,Fisch KM,Sasik R,Rosenthal SB,Kritzik M,Von Hoff D,Han H,Ideker T,Deshpande AJ,Lowy AM,Adams PD,Reya T

PA5-23148 was used in Immunohistochemistry to identify an orthogonal co-option of immuno-regulatory signals by pancreatic cancer stem cells, suggesting that autoimmune drugs should be evaluated as novel treatment strategies for pancreatic cancer patients.

Thu Apr 18 00:00:00 UTC 2019

生物信息学

蛋白别名: Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; Thymus orphan receptor; TOR

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基因别名: IMD42; NR1F3; RORC; RORG; RORgamma; RZR-GAMMA; RZRG; Thor; TOR

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UniProt ID: (Human) P51449, (Mouse) P51450

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Entrez Gene ID: (Human) 6097, (Mouse) 19885

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