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产品信息
H00006095-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RORA (NP_599024.1, 1 a.a. approximately 468 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MMYFVIAAMK AQIEIIPCKI CGDKSSGIHY GVITCEGCKG FFRRSQQSNA TYSCPRQKNC LIDRTSRNRC QHCRLQKCLA VGMSRDAVKF GRMSKKQRDS LYAEVQKHRM QQQQRDHQQQ PGEAEPLTPT YNISANGLTE LHDDLSNYID GHTPEGSKAD SAVSSFYLDI QPSPDQSGLD INGIKPEPIC DYTPASGFFP YCSFTNGETS PTVSMAELEH LAQNISKSHL ETCQYLREEL QQITWQTFLQ EEIENYQNKQ REVMWQLCAI KITEAIQYVV EFAKRIDGFM ELCQNDQIVL LKAGSLEVVF IRMCRAFDSQ NNTVYFDGKY ASPDVFKSLG CEDFISFVFE FGKSLCSMHL TEDEIALFSA FVLMSADRSW LQEKVKIEKL QQKIQLALQH VLQKNHREDG ILTKLICKVS TLRALCGRHT EKLMAFKAIY PDIVRLHFPP LYKELFTSEF EPAMQIDG
靶标信息
RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; retinoic acid receptor-related orphan receptor alpha; retinoid-related orphan receptor alpha; Retinoid-related orphan receptor-alpha; ROR Alpha; ROR-alpha; Roralpha; thyroid hormone nuclear receptor alpha variant 4; transcription factor RZR-alpha
基因别名: NR1F1; ROR1; ROR2; ROR3; RORA; RZR-ALPHA; RZRA
UniProt ID: (Human) P35398
Entrez Gene ID: (Human) 6095
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcription corepressor binding
transcription coactivator binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
beta-catenin binding
transcription factor binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding
C4 zinc finger nuclear receptor
angiogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
xenobiotic metabolic process
nitric oxide biosynthetic process
regulation of smoothened signaling pathway
positive regulation of vascular endothelial growth factor production
regulation of glucose metabolic process
regulation of steroid metabolic process
cerebellar Purkinje cell differentiation
cerebellar granule cell precursor proliferation
intracellular receptor signaling pathway
circadian regulation of gene expression
cellular response to sterol
muscle cell differentiation
positive regulation of circadian rhythm
regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
steroid hormone mediated signaling pathway
negative regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cGMP metabolic process
negative regulation of inflammatory response
regulation of transcription involved in cell fate commitment
triglyceride homeostasis
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to hypoxia
T-helper 17 cell differentiation
regulation of cholesterol homeostasis
