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产品信息
OSR00381W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 490-533 of mouse RPE65 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and shares 88% identity with human sequence.
Specificity of this antibody: RPE65.
靶标信息
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; modifier of retinal degeneration 1; retinal pigment epithelium 65-like; retinal pigment epithelium, 65 kDa; Retinal pigment epithelium-specific 65 kDa protein; Retinitis pigmentos; Retinoid isomerohydrolase; Retinol isomerase
基因别名: 65kDa; A930029L06Rik; LCA2; Mord1; rd12; RP20; Rpe65
UniProt ID: (Mouse) Q91ZQ5, (Rat) F1M8Q2
Entrez Gene ID: (Mouse) 19892, (Rat) 89826
retina homeostasis
neural retina development
regulation of rhodopsin gene expression
visual perception
insulin receptor signaling pathway
retinol metabolic process
retinal metabolic process
response to stimulus
detection of light stimulus involved in visual perception
retina development in camera-type eye
retina morphogenesis in camera-type eye
cellular response to electrical stimulus
circadian rhythm
response to light stimulus
camera-type eye development
