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产品信息
PA5-18890
产品规格
种属反应
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (EVKKNARKAPQPE) corresponding to the internal amino acids of RPE65 (aa 360-365).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10981243
产品详细信息
This antibody is predicted to react with canine and human based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
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生物信息学
蛋白别名: All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; retinal pigment epithelium 65-like; Retinal pigment epithelium-specific 65 kDa protein; Retinitis pigmentos; Retinoid isomerohydrolase; Retinol isomerase
基因别名: Rpe65
UniProt ID: (Rat) O70276
Entrez Gene ID: (Rat) 89826
retina homeostasis
neural retina development
regulation of rhodopsin gene expression
visual perception
circadian rhythm
insulin receptor signaling pathway
response to light stimulus
retinol metabolic process
retinal metabolic process
camera-type eye development
detection of light stimulus involved in visual perception
retina development in camera-type eye
retina morphogenesis in camera-type eye
cellular response to electrical stimulus
