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RPE65 Antibody (MA5-35821) in IHC (P)
Immunohistochemistry analysis of RPE65 in paraffin-embedded mouse retina. Samples were incubated with RPE65 Monoclonal antibody (Product # MA5-35821) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-35821
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1659
抗原
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human RPE65 (Q16518)
偶联物
形式
Liquid
浓度
1.65 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849721
产品详细信息
Immunogen sequence: TIWLEPEVLF SGPRQAFEFP QINYQKYCGK PYTYAYGLGL NHFVPDRLCK LNVKTKETWV WQEPDSYPSE PIFVSHPDAL EEDDGVVLSV VVSPGAGQKP A
靶标信息
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; modifier of retinal degeneration 1; retinal pigment epithelium 65-like; retinal pigment epithelium, 65 kDa; Retinal pigment epithelium-specific 65 kDa protein; Retinitis pigmentos; Retinoid isomerohydrolase; Retinol isomerase
基因别名: 65kDa; A930029L06Rik; LCA2; Mord1; rd12; RP20; Rpe65
UniProt ID: (Mouse) Q91ZQ5, (Rat) F1M8Q2
Entrez Gene ID: (Mouse) 19892, (Rat) 89826
retina homeostasis
neural retina development
regulation of rhodopsin gene expression
visual perception
insulin receptor signaling pathway
retinol metabolic process
retinal metabolic process
response to stimulus
detection of light stimulus involved in visual perception
retina development in camera-type eye
retina morphogenesis in camera-type eye
cellular response to electrical stimulus
circadian rhythm
response to light stimulus
camera-type eye development
