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产品信息
PA5-96283
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 161-315 of human RPH3AL (NP_0089181)
偶联物
形式
Liquid
浓度
2.45 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808085
产品详细信息
Immunogen sequence: KYILPLKTPG RADDPHFRPL PTEPAEREPR SSETSRIYTW ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK ESGGSVEAPR MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA PAADAAPAGP SSCLG; Positive Samples: BT-474, 22Rv1, SW620, NCI-H460; Cellular Location: Cytoplasm, Cytoplasmic vesicle, secretory vesicle membrane
靶标信息
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: No C2 domains protein; Rab effector Noc2; Rabphilin-3A-like protein
基因别名: Gm1753; NOC2; RPH3AL
UniProt ID: (Human) Q9UNE2, (Mouse) Q768S4
Entrez Gene ID: (Human) 9501, (Mouse) 380714
intracellular protein transport
exocytosis
vesicle fusion
regulation of calcium ion-dependent exocytosis
response to drug
glucose homeostasis
negative regulation of G-protein coupled receptor protein signaling pathway
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of protein secretion
synaptic vesicle exocytosis
regulation of exocytosis
