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RPL11 Antibody (PA5-101381) in ICC/IF
Immunofluorescent analysis of RPL11 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and RPL11 polyclonal antibody (Product # PA5-101381) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-101381
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RPL11, corresponding to a region within C-terminal amino acids.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850817
产品详细信息
Antibody detects endogenous levels of total RPL11.
靶标信息
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 60S ribosomal protein L11; cell growth-inhibiting protein 34; CLL-associated antigen KW-12; Large ribosomal subunit protein uL5; RP11-223J15.3
基因别名: 2010203J19Rik; DBA7; GIG34; L11; RPL11
UniProt ID: (Human) P62913, (Mouse) Q9CXW4, (Rat) P62914
Entrez Gene ID: (Human) 6135, (Mouse) 67025, (Rat) 362631
ribosomal large subunit assembly
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
rRNA processing
translation
translational initiation
protein targeting
SRP-dependent cotranslational protein targeting to membrane
viral transcription
protein localization to nucleus
ribosomal large subunit biogenesis
