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Immunogen sequence: MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM VMATVKKGKP ELRKKVHPAV VIRQRKSYRR KDGVFLYFED NAGVIVNNKG EMKGSAITGP VAKECADLWP RIASNAGSIA
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 60S ribosomal protein L17; 60S ribosomal protein L23; Large ribosomal subunit protein uL14; MGC111167; MGC117346; MGC72008; ribosomal protein L17
基因别名: 2810009A01Rik; L23; rpL17; RPL23
UniProt ID: (Human) P62829, (Mouse) P62830, (Rat) P62832
Entrez Gene ID: (Human) 9349, (Mouse) 65019, (Rat) 29282