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产品信息
H00027330-M02
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
6F2
抗原
RPS6KA6 (NP_055311.1, 636 a.a. approximately 745 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: RIGNGKFSLS GGNWDNISDG AKDLLSHMLH MDPHQRYTAE QILKHSWITH RDQLPNDQPK RNDVSHVVKG AMVATYSALT HKTFQPVLEP VAASSLAQRR SMKKRTSTGL
靶标信息
RPS6KA6 (RSK4) is a member of the RSK kinases family. RSK family members are activated by ERKs and mitogens and are unusual in that they contain 2 non-identical kinase domains. RSK4 encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; pp90RSK4; Ribosomal protein S6 kinase alpha-6; ribosomal protein S6 kinase, 90kDa, polypeptide 6; Ribosomal S6 kinase 4; RSK-4; S6K-alpha 6; S6K-alpha-6; S6KA6
基因别名: PP90RSK4; RGD1560817; RPS6KA6; RSK4
UniProt ID: (Human) Q9UK32
Entrez Gene ID: (Human) 27330, (Rat) 317203
protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
signal transduction
central nervous system development
negative regulation of embryonic development
negative regulation of ERK1 and ERK2 cascade
negative regulation of mesoderm development
