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RSK4 Antibody (PA5-99709) in ICC/IF
Immunocytochemistry analysis of RSK4 in HepG2 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with RSK4 polyclonal antibody (Product # PA5-99709) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-99709
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RPS6KA6(Accession Q9UK32), corresponding to amino acid residues P668-T718.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818642
产品详细信息
Antibody detects endogenous levels of total Rsk-4.
靶标信息
RPS6KA6 (RSK4) is a member of the RSK kinases family. RSK family members are activated by ERKs and mitogens and are unusual in that they contain 2 non-identical kinase domains. RSK4 encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; pp90RSK4; Ribosomal protein S6 kinase alpha-6; ribosomal protein S6 kinase, 90kDa, polypeptide 6; Ribosomal S6 kinase 4; RSK-4; S6K-alpha 6; S6K-alpha-6; S6KA6
基因别名: 2610524K04Rik; PP90RSK4; RPS6KA6; RSK4; S6K-alpha-6
UniProt ID: (Human) Q9UK32, (Mouse) Q7TPS0
Entrez Gene ID: (Human) 27330, (Mouse) 67071
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
ATP binding
kinase activity
nucleotide binding
ribosomal protein S6 kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
signal transduction
central nervous system development
negative regulation of embryonic development
negative regulation of ERK1 and ERK2 cascade
negative regulation of mesoderm development
regulation of translation
phosphorylation
intracellular signal transduction
