Invitrogen

RSPO2 Polyclonal Antibody

RSPO2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RSPO2 Antibody (PA5-25188) in IHC (P)

Immunohistochemistry analysis of RSPO2 in formalin fixed and paraffin embedded human lung carcinoma. Samples were incubated with RSPO2 polyclonal antibody (Product # PA5-25188) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.

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产品信息

PA5-25188

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:100

流式细胞分析 (Flow)

1:10-1:50

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 190-218 amino acids from the C-terminal region of human RSPO2

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2542688

产品详细信息

This antibody is predicted to react with mouse based on sequence homology.

靶标信息

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.

仅用于科研。不用于诊断过程。未经明确授权不得转售。