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产品信息
H00000864-B01P
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RUNX3 (AAH13362.1, 1 a.a. approximately 429 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MASNSIFDSF PTYSPTFIRD PSTSRRFTPP SPAFPCGGGG GKMGENSGAL SAQAAVGPGG RARPEVRSMV DVLADHAGEL VRTDSPNFLC SVLPSHWRCN KTLPVAFKVV ALGDVPDGTV VTVMAGNDEN YSAELRNASA VMKNQVARFN DLRFVGRSGR GKSFTLTITV FTNPTQVATY HRAIKVTVDG PREPRRHRQK LEDQTKPFPD RFGDLERLRM RVTPSTPSPR GSLSTTSHFS SQPQTPIQGT SELNPFSDPR QFDRSFPTLP TLTESRFPDP RMHYPGAMSA AFPYSATPSG TSISSLSVAG MPATSRFHHT YLPPPYPGAP QNQSGPFQAN PSPYHLYYGT SSGSYQFSMV AGSSSGGDRS PTRMLASCTS SAASVAAGNL MNPSLGGQSD GVEADGSHSN SPTALSTPGR MDEAVWRPY
靶标信息
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; CBF-alpha 3; CBF-alpha-3; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; Oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha C subunit; Runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2
基因别名: AML2; CBFA3; PEBP2A3; PEBP2aC; RUNX3
UniProt ID: (Human) Q13761
Entrez Gene ID: (Human) 864
negative regulation of transcription from RNA polymerase II promoter
ossification
chondrocyte differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein phosphorylation
hemopoiesis
regulation of cell differentiation
negative regulation of cell cycle
positive regulation of transcription, DNA-templated
peripheral nervous system neuron development
negative regulation of epithelial cell proliferation
response to transforming growth factor beta
