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产品信息
PA5-79944
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of mouse RUNX3 (186-205aa QKIEDQTKAFPDRFGDLRMR).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2747059
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acute myeloid leukemia 2 protein; CBF-alpha 3; CBF-alpha-3; core binding factor alpha 3; core-binding factor subunit alpha-3; oncogene AML-2; PEA2-alpha C; PEBP2-alpha C; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; Runt related transcription factor 3; runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2/CBFA3
基因别名: AML2; Cbfa3; Pebp2a3
Entrez Gene ID: (Mouse) 12399, (Rat) 156726
negative regulation of transcription from RNA polymerase II promoter
ossification
chondrocyte differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
axon guidance
hemopoiesis
neuron differentiation
hair follicle morphogenesis
neuron projection development
interferon-gamma production
mRNA transcription from RNA polymerase II promoter
regulation of cell differentiation
negative regulation of cell cycle
cell maturation
negative regulation of epithelial cell proliferation
positive regulation of extrinsic apoptotic signaling pathway
biological_process
