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RXRG Antibody (PA5-110337) in IHC (P)
Immunohistochemistry analysis of RXRG in paraffin-embedded mouse testis. Samples were incubated with RXRG Polyclonal antibody (Product # PA5-110337) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-110337
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human RXRG (NP_008848.1).
偶联物
形式
Liquid
浓度
0.41 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855748
产品详细信息
Immunogen sequence: MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKH
靶标信息
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; retinoic X receptor gamma-1; retinoid X receptor; Retinoid X receptor gamma; retinoid X receptor, gamma; RXR gamma; RXR gamma-1
基因别名: NR2B3; RXRC; RXRG
UniProt ID: (Human) P48443, (Rat) Q5BJR8, (Mouse) P28705
Entrez Gene ID: (Human) 6258, (Rat) 83574, (Mouse) 20183
RNA polymerase II regulatory region sequence-specific DNA binding
steroid hormone receptor activity
9-cis retinoic acid receptor activity
protein binding
zinc ion binding
sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
transcription initiation from RNA polymerase II promoter
steroid hormone mediated signaling pathway
retinoic acid receptor signaling pathway
protein homotetramerization
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
transcription, DNA-templated
transcription from RNA polymerase II promoter
peripheral nervous system development
heart development
skeletal muscle tissue development
response to organic cyclic compound
neuron differentiation
regulation of myelination
response to retinoic acid
cellular response to hormone stimulus
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
